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Margarita Rosa de Francisco as Carolina Álvarez, Colombian journalist working for El Tiempo.Gaston Velandia as José Serrano, General of the Colombian National Police.Brett Cullen as Ambassador Arthur Crosby, a former Navy officer sent as US Ambassador to Colombia by George H.Juan Pablo Shuk as Colonel Hugo Martínez, the commander of Search Bloc.Juan Sebastián Calero as Navegante, a violent associate of the Cali Cartel who works as their top henchman.Juan Carlos Messier as Gustavo Calderón, a corrupt police captain who is murdered by the Cali cartel.
José María Yazpik as Amado Carrillo Fuentes - a Mexican drug trafficker allied with Pacho and the Cali cartel, known as "The Lord of the Skies". Matt Whelan as Daniel Van Ness – DEA agent partnered with Feistl. Michael Stahl-David as Chris Feistl – DEA agent working under Peña. Kerry Bishé as Christina Jurado – the American wife of a banker affiliated with the Cali cartel. Andrea Londo as María Salazar – wife of a Colombian drug-lord affiliated with the North Valley cartel. Eric Lange as Bill Stechner – the CIA Station Chief in Colombia. Arturo Castro as David Rodríguez – Miguel's son. Javier Cámara as Guillermo Pallomari – the chief accountant of the Cali Cartel. Matias Varela as Jorge Salcedo Cabrera – the Cali Cartel's head of security. Pêpê Rapazote as José "Chepe" Santacruz-Londoño – a high-ranking member of the Cali Cartel who oversees the group's operations in New York City. Francisco Denis as Miguel Rodríguez Orejuela – a high-ranking member of the Cali Cartel and Gilberto's younger brother. Alberto Ammann as Hélmer "Pacho" Herrera – a Colombian drug lord and high-ranking member of the Cali Cartel. Damián Alcázar as Gilberto Rodríguez Orejuela – the leader of the Cali Cartel and one of Pablo Escobar's primary rivals.
Pedro Pascal as Javier Peña, DEA agent tasked with taking down the Cali cartel.